(+)-Hanfangichin B
Fangchinoline
CAS: 436-77-1;33889-68-8
Molecular Formula: C37H40N2O6
(+)-Hanfangichin B - Names and Identifiers
| Name | Fangchinoline |
| Synonyms | (+)-limacine FANGCHINOLINE Fangchinoline Tetrandrine B HANFANGCHIN B (+)-Fangchinoline (+)-Hanfangichin B FANGCHINOLINE (RG) 12-O-MethylatherosperMoline 6,6',12-trimethoxy-2,2'-dimethylberbaman-7-ol (1beta)-6,6',12-Trimethoxy-2,2'-dimethylberbaman-7-ol (1-beta)-2,2'-dimethyl-6,6',12-trimethoxyberbaman-7-ol |
| CAS | 436-77-1 33889-68-8 |
| InChI | InChI=1/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3 |
(+)-Hanfangichin B - Physico-chemical Properties
| Molecular Formula | C37H40N2O6 |
| Molar Mass | 608.72 |
| Density | 1.204±0.06 g/cm3(Predicted) |
| Melting Point | 240～242℃ |
| Boling Point | 709.7±60.0 °C(Predicted) |
| Specific Rotation(α) | ＋255．1°（），＋275°（C=0．57，） |
| Flash Point | 383°C |
| Solubility | 100 mg/mL in DMSO |
| Vapor Presure | 8.25E-21mmHg at 25°C |
| Appearance | Brown powder |
| Color | White to Orange to Green |
| pKa | 9.38±0.20(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.601 |
| MDL | MFCD00221726 |
| Physical and Chemical Properties | From the tetrandra S. Moore, a plant of the family tetrandra |
(+)-Hanfangichin B - Reference Information
| overview | [1-3] Fangzonolinine (Fangchinoline), also known as HanFangji and Aquilaria sinensis, is the dry root of Fangji plant FenFangji. It has many biological functions such as anti-inflammatory and analgesic, antioxidant, non-specific blocking of calcium ion channels, inhibiting histamine release, dilating coronary arteries, reducing myocardial oxygen consumption, inhibiting platelet aggregation, lowering blood pressure, lowering blood sugar, etc. In some cells, the anti-tumor effect can be achieved by blocking the cell cycle and inducing autophagy apoptosis. Fanghexonoline can significantly inhibit the proliferation and metastasis of A375 cells, and can be used as a potential chemotherapy drug for the treatment of melanoma. picture: chinese defense self |
| pharmacological action | [4] Fangzonolin (fangchinoline,FAN) is often used as an analgesic, anti-rheumatic and anti-hypertensive drug in traditional Chinese medicine. In recent years, its anti-cancer effect has attracted people's attention. Literature indicates that it can inhibit tumor cells by inducing apoptosis, blocking cell cycle progression and inhibiting tumor cell invasion. In addition, as one of the main alkaloids contained in the Fangji plant Fangji, Fanghexine has obvious analgesic, antipyretic, anti-inflammatory, diuretic, coronary artery expansion, blood pressure lowering, anti-cancer and other effects. High-dose or long-term use will have certain toxicity to the liver and kidney, of which liver damage is the most serious, and the degree of damage is proportional to the drug dose. In addition, Fanghexanolin may become a potential drug for the treatment of prostate cancer. The expression of its pro-apoptotic protein Bax and activated Caspase-3 protein also increased significantly, while the Bcl-2 of inhibiting apoptosis protein decreased correspondingly. picture: structure diagram of nongenoline |
| determination method | [5] the determination methods of tetrandolinine (FAN) mainly include high performance liquid chromatography (HPLC) , thin layer chromatography (TLC) and capillary electrophoresis (CE). recently, chemiluminescence method has also been reported. The method is based on the oxidation of Fangzonolin base by potassium permanganate under acidic conditions to produce chemiluminescence, and a new method for the determination of Fangzonolin base by potassium permanganate academic luminescence system has been established. The method is simple, fast and sensitive. has been successfully used for the determination of Fangzonolin content in Fangji. |
| References | [1] Guo Bingyu, Zhang Yu, Hui Qiang, et al. Fangjianolin Inhibits Proliferation and Metastasis of Melanoma [J]. Practical Drugs and Clinics, 2016, 19(10):1219-1223. [2] Xu Xueqin, Ou Hailing, Wang Yuanfu, etc. Determination of Fangjianolin in Fangji by Chemiluminescence [J]. Journal of Fuzhou University, 2008(5):763-766. [3] Guo Bingyu, Zhang Yu, Hui Qiang, etc. Fangjianolin Enhances Apoptosis of Melanoma Cells Induced by Gemcitabine [J]. Journal of Clinical Military Medicine, 2015, 43(10):1026-1030. [4] Wu Qiuhua, Wang Chun, wang Zhi, et al. Study on the Interaction between Fangjianolin and Bovine Serum Albumin [J]. Spectroscopy and Spectral Analysis, 2007, 27(12):2498-2501. [5] Huang Jianguo. Study on the Mechanism of Fangjianolin Inhibiting Proliferation of Prostate Cancer PC-3 Cells [D]. Huazhong University of Science and Technology, 2010. |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: anti-inflammatory and analgesic effects; antihypertensive effects; anti-tumor effects; anti-platelet aggregation effects. |
Last Update：2024-04-09 15:16:50
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